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VASCULAR DEVELOPMENT AND DISEASE

TEAM LEADER : Anne Eichmann
Mail : anne.eichmann@inserm.fr
PHONE :+33 1 53 98 79 54
LOCALISATION : Lab 360, 3rd floor
DOCTORAL SCHOOL : Bio-Sorbonne Paris Cité, Department of Cellular and Molecular Biology, Physiology and Pathology

TEAM PUBLICATIONS

Selected publications (2018-2023)
 

Chylomicrons regulate lacteal permeability and intestinal lipid absorption

Georgia Zarkada, Xun Chen, Xuetong Zhou, Martin Lange, Lei Zeng, Wenyu Lv, Xuan Zhang, Yunhua Li, Weibin Zhou, Keli Liu, Dongying Chen, Nicolas Ricard, James Liao, Young-Bum Kim, Rui Benedito, Lena Claesson-Welsh, Kari Alitalo, Michael Simons, Rong Ju, Xuri Li, Anne Eichmann, Feng Zhang

Circulation Research 2023 133 (4), 333-349

 

CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma

Luiz Henrique Geraldo, Celina Garcia, Yunling Xu, Felipe Saceanu Leser, Izabella Grimaldi, Eduardo Sabino de Camargo Magalhães, Joost Dejaegher, Lien Solie, Cláudia Maria Pereira, Ana Helena Correia, Steven De Vleeschouwer, Bertrand Tavitian, Nathalie Henriques Silva Canedo, Thomas Mathivet, Jean-Leon Thomas, Anne Eichmann, Flavia Regina Souza Lima

Cellular and Molecular Life Sciences 2023 80 (7), 179

 

Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

Sungwoon Lee, Hubertus Schleer, Hyojin Park, Erika Jang, Michael Boyer, Bo Tao, Ana Gamez-Mendez, Abhishek Singh, Ewa Folta-Stogniew, Xinbo Zhang, Lingfeng Qin, Xue Xiao, Lin Xu, Junhui Zhang, Xiaoyue Hu, Evanthia Pashos, George Tellides, Philip W Shaul, Warren L Lee, Carlos Fernandez-Hernando, Anne Eichmann, William C Sessa

Nature Cardiovascular Research 2023, 1-11

 

Environmental and intrinsic modulations of venous differentiation

Laurence Pibouin-Fragner, Anne Eichmann, Luc Pardanaud

Cellular and Molecular Life Sciences 2022 79 (9), 491

 

Conserved meningeal lymphatic drainage circuits in mice and humans

Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas

Journal of Experimental Medicine 2022 219 (8), e20220035

 

Endothelial Unc5B controls blood-brain barrier integrity

Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L Ackerman, Anne Eichmann

Nature Communications 2022 13 (1), 1169

 

Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia

Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C Sessa, Claudio A Franco, Martin A Schwartz, Anne Eichmann

Circulation 2021 144 (10), 805-822

 

Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development

Jinyu Li, Luiz Henrique Geraldo, Alexandre Dubrac, Georgia Zarkada, Anne Eichmann

Journal of the American Society of Nephrology 2021: JASN 32 (9), 2255

 

SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia

Luiz H Geraldo, Yunling Xu, Laurent Jacob, Laurence Pibouin-Fragner, Rohit Rao, Nawal Maissa, Maïté Verreault, Nolwenn Lemaire, Camille Knosp, Corinne Lesaffre, Thomas Daubon, Joost Dejaegher, Lien Solie, Justine Rudewicz, Thomas Viel, Bertrand Tavitian, Steven De Vleeschouwer, Marc Sanson, Andreas Bikfalvi, Ahmed Idbaih, Q Richard Lu, Flavia RS Lima, Jean-Leon Thomas, Anne Eichmann, Thomas Mathivet

The Journal of clinical investigation 2021 131 (16)

 

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

Georgia Zarkada, Joel P Howard, Xue Xiao, Hyojin Park, Mathilde Bizou, Severine Leclerc, Steffen E Künzel, Blanche Boisseau, Jinyu Li, Gael Cagnone, Jean Sebastien Joyal, Gregor Andelfinger, Anne Eichmann, Alexandre Dubrac

Developmental cell 2021 56 (15), 2237-2251. e6

 

Stop the Divide and Build Coronary Arteries

G Zarkada, A Eichmann

Developmental Cell 2021 56 (3), 255-256

 

Lymphatic endothelial cell junctions: molecular regulation in physiology and diseases

Feng Zhang, Georgia Zarkada, Sanjun Yi, Anne Eichmann

Frontiers in Physiology  2020 11, 509

 

Anatomy and function of the vertebral column lymphatic network in mice

Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann, Jean-Leon Thomas

Nature communications 2019 10 (1), 4594

 

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann

Nature communications 2019 10 (1), 2350

 

SMAD4 prevents flow induced arteriovenous malformations by inhibiting casein kinase 2

Roxana Ola, Sandrine H Künzel, Feng Zhang, Gael Genet, Raja Chakraborty, Laurence Pibouin-Fragner, Kathleen Martin, William Sessa, Alexandre Dubrac, Anne Eichmann

Circulation 2018 138 (21), 2379-2394

 

NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

Alexandre Dubrac, Steffen E Künzel, Sandrine H Künzel, Jinyu Li, Rachana Radhamani Chandran, Kathleen Martin, Daniel M Greif, Ralf H Adams, Anne Eichmann

Nature communications 2018 9 (1), 3463

 

Lacteal junction zippering protects against diet-induced obesity

Feng Zhang, Georgia Zarkada, Jinah Han, Jinyu Li, Alexandre Dubrac, Roxana Ola, Gael Genet, Kevin Boyé, Pauline Michon, Steffen E Künzel, Joao Paulo Camporez, Abhishek K Singh, Guo-Hua Fong, Michael Simons, Patrick Tso, Carlos Fernández-Hernando, Gerald I Shulman, William C Sessa, Anne Eichmann

Science 2018 361 (6402), 599-603