Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity
Jessica Furtado, Luiz Henrique Geraldo, Felipe Saceanu Leser, Bartlomiej Bartkowiak, Mathilde Poulet, Hyojin Park, Mark Robinson, Laurence Pibouin-Fragner 3 , Anne Eichmann #, Kevin Boyé#
Proc Natl Acad Sci U S A. 2024;121(52):e2408674121
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells
Luiz Henrique Geraldo, Yunling Xu, Gaspard Mouthon, Jessica Furtado, Felipe Saceanu Leser, Levi L Blazer, Jarrett J Adams, Sophia Zhang, Lana Zheng, Eric Song, Mark E Robinson, Jean-Leon Thomas, Sachdev S Sidhu, Anne Eichmann
Sci Transl Med. 2024 Nov 20;16(774)
Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature
Ilaria Del Gaudio#, Anja Nitzsche#, Kevin Boyé, Philippe Bonnin, Mathilde Poulet, Toan Q Nguyen, Ludovic Couty, Hoa T T Ha, Dat T Nguyen, Amaury Cazenave-Gassiot, Khaoula Ben Alaya, Patrice Thérond, Jerold Chun, Markus R Wenk, Richard L Proia, Daniel Henrion, Long N Nguyen, Anne Eichmann, Eric Camerer
Cardiovasc Res 2024 120 (14), 1794-1810
Vascular development, remodeling and maturation
Jessica Furtado, Anne Eichmann
Curr Top Dev Biol. 2024;159:344-370.
Chylomicrons regulate lacteal permeability and intestinal lipid absorption
Georgia Zarkada, Xun Chen, Xuetong Zhou, Martin Lange, Lei Zeng, Wenyu Lv, Xuan Zhang, Yunhua Li, Weibin Zhou, Keli Liu, Dongying Chen, Nicolas Ricard, James Liao, Young-Bum Kim, Rui Benedito, Lena Claesson-Welsh, Kari Alitalo, Michael Simons, Rong Ju, Xuri Li, Anne Eichmann, Feng Zhang
Circulation Research 2023 133 (4), 333-349
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
Luiz Henrique Geraldo, Celina Garcia, Yunling Xu, Felipe Saceanu Leser, Izabella Grimaldi, Eduardo Sabino de Camargo Magalhães, Joost Dejaegher, Lien Solie, Cláudia Maria Pereira, Ana Helena Correia, Steven De Vleeschouwer, Bertrand Tavitian, Nathalie Henriques Silva Canedo, Thomas Mathivet, Jean-Leon Thomas, Anne Eichmann, Flavia Regina Souza Lima
Cellular and Molecular Life Sciences 2023 80 (7), 179
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Sungwoon Lee, Hubertus Schleer, Hyojin Park, Erika Jang, Michael Boyer, Bo Tao, Ana Gamez-Mendez, Abhishek Singh, Ewa Folta-Stogniew, Xinbo Zhang, Lingfeng Qin, Xue Xiao, Lin Xu, Junhui Zhang, Xiaoyue Hu, Evanthia Pashos, George Tellides, Philip W Shaul, Warren L Lee, Carlos Fernandez-Hernando, Anne Eichmann, William C Sessa
Nature Cardiovascular Research 2023, 1-11
Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
Thanh Nha Uyen Le, Toan Q Nguyen, Pazhanichamy Kalailingam, Yen Thi Kim Nguyen, Viresh Krishnan Sukumar, Clarissa Kai Hui Tan, Farhana Tukijan , Ludovic Couty, Zafrul Hasan, Ilaria Del Gaudio, Markus R Wenk, Amaury Cazenave-Gassiot, Eric Camerer, Long N Nguyen
Cell Rep. 2022 Aug 16;40(7):111208.
Environmental and intrinsic modulations of venous differentiation
Laurence Pibouin-Fragner, Anne Eichmann, Luc Pardanaud
Cellular and Molecular Life Sciences 2022 79 (9), 491
Conserved meningeal lymphatic drainage circuits in mice and humans
Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas
Journal of Experimental Medicine 2022 219 (8), e20220035
Distinct GEFs Couple S1PR1 to Rac for Endothelial Barrier Enhancement and Lymphocyte Trafficking
Ilaria Del Gaudio, Eric Camerer
Arterioscler Thromb Vasc Biol. 2022 Jul;42(7):903-905
Endothelial Unc5B controls blood-brain barrier integrity
Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L Ackerman, Anne Eichmann
Nature Communications 2022 13 (1), 1169
Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia
Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C Sessa, Claudio A Franco, Martin A Schwartz, Anne Eichmann
Circulation 2021 144 (10), 805-822
Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development
Jinyu Li, Luiz Henrique Geraldo, Alexandre Dubrac, Georgia Zarkada, Anne Eichmann
Journal of the American Society of Nephrology 2021: JASN 32 (9), 2255
SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia
Luiz H Geraldo, Yunling Xu, Laurent Jacob, Laurence Pibouin-Fragner, Rohit Rao, Nawal Maissa, Maïté Verreault, Nolwenn Lemaire, Camille Knosp, Corinne Lesaffre, Thomas Daubon, Joost Dejaegher, Lien Solie, Justine Rudewicz, Thomas Viel, Bertrand Tavitian, Steven De Vleeschouwer, Marc Sanson, Andreas Bikfalvi, Ahmed Idbaih, Q Richard Lu, Flavia RS Lima, Jean-Leon Thomas, Anne Eichmann, Thomas Mathivet
The Journal of clinical investigation 2021 131 (16)
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
Georgia Zarkada, Joel P Howard, Xue Xiao, Hyojin Park, Mathilde Bizou, Severine Leclerc, Steffen E Künzel, Blanche Boisseau, Jinyu Li, Gael Cagnone, Jean Sebastien Joyal, Gregor Andelfinger, Anne Eichmann, Alexandre Dubrac
Developmental cell 2021 56 (15), 2237-2251. e6
Stop the Divide and Build Coronary Arteries
G Zarkada, A Eichmann
Developmental Cell 2021 56 (3), 255-256
Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke
Anja Nitzsche#, Marine Poittevin#, Ammar Benarab#, Philippe Bonnin#, Giuseppe Faraco, Hiroki Uchida, Julie Favre, Lidia Garcia-Bonilla, Manuela C L Garcia, Pierre-Louis Léger, Patrice Thérond , Thomas Mathivet, Gwennhael Autret, Véronique Baudrie, Ludovic Couty, Mari Kono, Aline Chevallier, Hira Niazi, Pierre-Louis Tharaux, Jerold Chun, Susan R Schwab , Anne Eichmann, Bertrand Tavitian, Richard L Proia 11, Christiane Charriaut-Marlangue, Teresa Sanchez, Nathalie Kubis, Daniel Henrion, Costantino Iadecola, Timothy Hla, Eric Camerer
Circ Res. 2021 Feb 5;128(3):363-382
Platelets maintain vascular barrier function in the absence of injury or inflammation
Benoit Ho-Tin-Noé, Ophélie Le Chapelain, Eric Camerer
J Thromb Haemost 2021;19:1145-48
Lymphatic endothelial cell junctions: molecular regulation in physiology and diseases
Feng Zhang, Georgia Zarkada, Sanjun Yi, Anne Eichmann
Frontiers in Physiology 2020 11, 509
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
Eric Engelbrecht#, Michel V Levesque#, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi, Andrew Kuo, Sasha A Singh, Masanori Aikawa, Kristina Holton, Richard L Proia, Mari Kono, William T Pu, Eric Camerer , Christer Betsholtz, Timothy Hla
Elife. 2020 Feb 24;9:e52690
Anatomy and function of the vertebral column lymphatic network in mice
Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann, Jean-Leon Thomas
Nature Communications 2019 10 (1), 4594
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Nature Communications 2019 10 (1), 2350
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing
Hira Niazi, Nesrine Zoghdani, Ludovic Couty, Alexandre Leuci, Anja Nitzsche, Maria L Allende, Boubacar Mariko, Rameez Ishaq , Yetki Aslan, Pierre Hadrien Becker, Salomé L Gazit, Sonia Poirault-Chassac, Benoit Decouture, Veronique Baudrie, Erica De Candia, Mari Kono, Ammar Benarab, Pascale Gaussem, Pierre-Louis Tharaux, Jerold Chun, Sylvain Provot, Najet Debili, Patrice Therond, Richard L Proia, Christilla Bachelot-Loza, Eric Camerer
Blood Adv 2019;3:1702-1713
SMAD4 prevents flow induced arteriovenous malformations by inhibiting casein kinase 2
Roxana Ola, Sandrine H Künzel, Feng Zhang, Gael Genet, Raja Chakraborty, Laurence Pibouin-Fragner, Kathleen Martin, William Sessa, Alexandre Dubrac, Anne Eichmann
Circulation 2018 138 (21), 2379-2394
NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
Alexandre Dubrac, Steffen E Künzel, Sandrine H Künzel, Jinyu Li, Rachana Radhamani Chandran, Kathleen Martin, Daniel M Greif, Ralf H Adams, Anne Eichmann
Nature Communications 2018 9 (1), 3463
Lacteal junction zippering protects against diet-induced obesity
Feng Zhang, Georgia Zarkada, Jinah Han, Jinyu Li, Alexandre Dubrac, Roxana Ola, Gael Genet, Kevin Boyé, Pauline Michon, Steffen E Künzel, Joao Paulo Camporez, Abhishek K Singh, Guo-Hua Fong, Michael Simons, Patrick Tso, Carlos Fernández-Hernando, Gerald I Shulman, William C Sessa, Anne Eichmann
Science 2018 361 (6402), 599-603
Platelets and vascular integrity: how platelets prevent bleeding in inflammation.
Benoit Ho-Tin-Noé, Yacine Boulaftali, Eric Camerer
Blood. 2018;131:277-288.
