Mail : clement.cochain@inserm.fr
PHONE :+33 1 53 98 80 41
Atherosclerosis
Myocardial infarction
Inflammation
Macrophages
Neutrophils
Single-cell technologies
Physiopathologie, métabolisme, nutrition
Clément Cochain received his PhD from Université Paris 7 in 2011. His doctorate work was performed in the Paris Cardiovascular Research Center under the supervision of J-S Silvestre, and focused on the role of chemokines and their receptors in the initiation and resolution of inflammation during tissue repair after ischemic injury. In 2012, he moved to the lab of Prof. Alma Zernecke (Würzburg, Germany) where he worked on the immune pathogenesis of atherosclerosis, with projects investigating various aspects of the adaptive and innate immune response in vascular inflammation. From 2018 to 2024, Clément Cochain led a junior research group at the University Hospital Würzburg, Germany, where he investigated the heterogeneity and determinants of innate immune cell function in atherosclerosis and myocardial infarction using single-cell technologies. Since April 2024, Clément Cochain holds the INSERM Junior Professor Chair ‘Multi-organ dysfunction and cardiovascular pathology in metabolic diseases’ at the Paris Cardiovascular Research Center.
2024-ongoing: INSERM Junior Professor Chair: Multi-organ dysfunction and cardiovascular pathology in metabolic diseases. Paris Cardiovascular Research Center (PARCC) INSERM-U970, Université Paris Cité, Paris, France
2023-2024: Junior Group leader, Institute of Experimental Biomedicine, University Hospital Würzburg, Germany
2018-2022: Junior Group leader, Comprehensive Heart Failure Center Würzburg, University Hospital Würzburg, Germany
2012-2017: Postdoctoral research fellow, A. Zernecke Group, Institute of Experimental Biomedicine University Hospital Würzburg, Germany
2007- 2011 Doctoral research fellow, JS Silvestre Group Paris Cardiovascular Research Center, Paris, France
2018-2024: junior group leader, research work focusing on applying single-cell technologies to unravel innate immune cell heterogeneity and functional determinants in cardiovascular diseases, focusing on neutrophils and macrophages in atherosclerosis and myocardial infarction, in particular uncovering the transcriptomic profile and functions of TREM2+ macrophages in cardiovascular diseases (see PMIDs: 36190844, 35950218, 34897380, 32811295, 38974464).
2012-2017: postdoc work focusing on the immune pathogenesis of atherosclerosis, with projects related to T cell subsets and co-inhibitory pathways in atherosclerosis, and characterization of the macrophage landscape in atherosclerosis (see PMIDs: 29545365, 28168325, 25991812, 24691202).
2007-2011: PhD work focusing on the role of chemokines and their receptors in the initiation and resolution of inflammation in ischemic tissue repair (see PMIDs: 22796582, 20501509).