Atherosclerosis, and its complications such as myocardial infarction, represent the leading cause of death worldwide. These cardiovascular diseases are part of a group of cardiometabolic disorders encompassing obesity, hypertension, liver and renal diseases, and diabetes mellitus. While atherosclerosis and myocardial infarction locally affect arteries and the heart, they represent the endpoints of organism-wide processes controlling metabolic homeostasis, blood pressure, and immune homeostasis, thus representing multi-organ diseases. Our research group investigates innate immune cells, in particular monocytes, macrophages and neutrophils, as essential actors in multi-organ disease in atherosclerosis, myocardial infarction and cardiometabolic disorders. We apply state-of-the art techniques of single-cell profiling and spatial gene expression analysis in experimental models of cardiometabolic diseases, to better understand the cellular and molecular mechanisms underlying innate immune cells contribution to  atherosclerosis and to tissue remodelling after myocardial infarction.