08-Publications

Selected publications

VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.

Kosmider O, Possémé C, Templé M, Corneau A, Carbone F, Duroyon E, Breillat P, Chirayath TW, Oules B, Sohier P, Luka M, Gobeaux C, Lazaro E, Outh R, Le Guenno G, Lifermann F, Berleur M, Le Mene M, Friedrich C, Lenormand C, Weitten T, Guillotin V, Burroni B, Boussier J, Willems L, Aractingi S, Dionet L, Tharaux PL, Vergier B, Raynaud P, Ea HK, Ménager M, Duffy D, Terrier B. Nat Commun. 2024 Jan 30;15(1):910. doi: 10.1038/s41467-024-44811-4. PMID: 37678257

Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy. 

Salemkour Y, Yildiz D, Dionet L, ‘t Hart DC, Verheijden KAT, Saito R, Mahtal N, Delbet JD, Letavernier E, Rabant M, Karras A, van der Vlag J, Nijenhuis T, Tharaux PL, Lenoir O. J Am Soc Nephrol. 2023 Nov 1;34(11):1823-1842. doi: 10.1681/ASN.0000000000000212. Epub 2023 Sep 6.PMID: 37678257

Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study.

Loupy A, Goutaudier V, Giarraputo A, Mezine F, Morgand E, Robin B, Khalil K, Mehta S, Keating B, Dandro A, Certain A, Tharaux PL, Narula N, Tissier R, Giraud S, Hauet T, Pass HI, Sannier A, Wu M, Griesemer A, Ayares D, Tatapudi V, Stern J, Lefaucheur C, Bruneval P, Mangiola M, Montgomery RA.Lancet. 2023 Sep 30;402(10408):1158-1169. doi: 10.1016/S0140-6736(23)01349-1. Epub 2023 Aug 17.PMID: 37598688

Autophagy protein 5 controls flow-dependent endothelial functions.

Nivoit P, Mathivet T, Wu J, Salemkour Y, Sankar DS, Baudrie V, Bourreau J, Guihot AL, Vessieres E, Lemitre M, Bocca C, Teillon J, Le Gall M, Chipont A, Robidel E, Dhaun N, Camerer E, Reynier P, Roux E, Couffinhal T, Hadoke PWF, Silvestre JS, Guillonneau X, Bonnin P, Henrion D, Dengjel J, Tharaux PL, Lenoir O.Cell Mol Life Sci. 2023 Jul 18;80(8):210. doi: 10.1007/s00018-023-04859-9.PMID: 37460898

Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial. 

CORIMUNO-19 Collaborative group. Lancet Rheumatol. 2022 Jan;4(1):e24-e32. doi: 10.1016/S2665-9913(21)00315-5. Epub 2021 Nov 17. PMID: 34812424

Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial.

CORIMUNO-19 Collaborative group.Lancet Respir Med. 2021 Mar;9(3):295-304. doi: 10.1016/S2213-2600(20)30556-7. Epub 2021 Jan 22.PMID: 33493450

Calpastatin prevents Angiotensin II-mediated podocyte injury through maintenance of autophagy.

Bensaada I, Robin B, Perez J, Salemkour Y, Chipont A, Camus M, Lemoine M, Guyonnet L, Lazareth H, Letavernier E, Hénique C, Tharaux PL, Lenoir O.Kidney Int. 2021 Jul;100(1):90-106. doi: 10.1016/j.kint.2021.02.024. Epub 2021 Mar 3.PMID: 33675847

Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury.

Guyonnet L, Czopek A, Farrah TE, Baudrie V, Bonnin P, Chipont A, Lenoir O, Sennlaub F, Roubeix C, Webb DJ, Kluth DC, Bailey MA, Tharaux PL, Dhaun N.Kidney Int. 2020 Nov;98(5):1193-1209. doi: 10.1016/j.kint.2020.05.042. Epub 2020 Jun 20.PMID: 32569653 

The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.

Lazareth H, Henique C, Lenoir O, Puelles VG, Flamant M, Bollée G, Fligny C, Camus M, Guyonnet L, Millien C, Gaillard F, Chipont A, Robin B, Fabrega S, Dhaun N, Camerer E, Kretz O, Grahammer F, Braun F, Huber TB, Nochy D, Mandet C, Bruneval P, Mesnard L, Thervet E, Karras A, Le Naour F, Rubinstein E, Boucheix C, Alexandrou A, Moeller MJ, Bouzigues C, Tharaux PL. Nat Commun. 2019 Jul 24;10(1):3303. doi: 10.1038/s41467-019-11013-2. PMID: 31341160

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis.

Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL.Nat Commun. 2017 Nov 28;8(1):1829. doi: 10.1038/s41467-017-01885-7.PMID: 29184126 

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease.

Koehl B, Nivoit P, El Nemer W, Lenoir O, Hermand P, Pereira C, Brousse V, Guyonnet L, Ghinatti G, Benkerrou M, Colin Y, Le Van Kim C, Tharaux PL.Haematologica. 2017 Jul;102(7):1161-1172. doi: 10.3324/haematol.2016.156869. Epub 2017 Apr 6.PMID: 28385784 

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis.

Lenoir O, Jasiek M, Hénique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL.Autophagy. 2015;11(7):1130-45. doi: 10.1080/15548627.2015.1049799.PMID: 26039325