PARCC

INTEGRATIVE PHYSIOPATHOLOGY AND THERAPY OF CARDIAC DISEASE

TEAM LEADERS : Jean-Sébastien Silvestre and Jean-Sébastien Hulot

Mail : jean-sebastien.silvestre@inserm.fr / jean-sebastien.hulot@inserm.fr

PHONE :+33 1 53 98 79 66 (JS Silvestre) / +33 1 56 09 20 17 (JS Hulot)

LOCATION : Lab 216 (Group JS Silvestre) & Lab 362-369 (Group JS Hulot) & Lab 174 (Group P Menasché)

DOCTORAL SCHOOL : Bio-Sorbonne Paris Cité, Department of Cellular and Molecular Biology, Physiology and Pathology. Médicament, Toxicologie, Chimie, Imageries «MTCI»

SELECTED PUBLICATIONS

Coly PM, Chatterjee S, Mezine F, Jekmek CE, Devue C, Nipoti T, Mazlan S, Corona ML, Dingli F, Loew D, van Niel G, Loyer X, Boulanger CM. Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM-1 cell adhesion molecules. J Extracell Vesicles. 2024 Oct;13(10):e12414. doi: 10.1002/jev2.12414.

Hulot JS, Janiak P, Boutinaud P, Boutouyrie P, Chézalviel-Guilbert F, Christophe JJ, Cohen A, Damy T, Djadi-Prat J, Firat H, Hervé PY, Isnard R, Jondeau G, Mousseaux E, Pernot M, Prot P, Tyl B, Soulat G, Logeart D; PACIFIC consortium. Rationale and design of the PACIFIC-PRESERVED (PhenomApping, ClassiFication and Innovation for Cardiac dysfunction in patients with heart failure and PRESERVED left ventricular ejection fraction) study. Arch Cardiovasc Dis. 2024 May;117(5):332-342.

Al Sayed ZR, Pereira C, Le Borgne R, Viaris de Lesegno C, Jouve C, Pénard E, Mallet A, Masurkar N, Loussouarn G, Verbavatz JM, Lamaze C, Trégouët DA, Hulot JS. CAVIN-1 mediated hERG dynamics: a novel mechanism underlying the interindividual variability in drug-induced long QT. Circulation. 2024 Apr 29. doi: 10.1161/CIRCULATIONAHA.123.063917. Online ahead of print.

Vermersch E, Neuvendel S, Jouve C, Ruiz-Velasco A, Pereira C, Seguret M, Cattin-Messaoudi ME, Lotfi S, Dorval T, Berson P, Hulot JS. Hsa-miRNA-548v controls the viscoelastic properties of human cardiomyocytes and improve their relaxation rates. JCI Insight. 2024:e161356. doi: 10.1172/jci.insight.161356

Masurkar N, Bouvet M, Logeart D, Claude O, Roux M, Delacroix C, Bergerot D, Mercadier JJ, Sirol M, Gellen B, Livrozet M, Fayol A, Robidel E, Trégouët DA, Marazzi G, Sassoon D, Valente M, Hulot JS. The novel cardiokine GDF3 predicts adverse fibrotic remodeling post-myocardial infarction. Circulation 2023, 147:498-511

Lecoeur E, Domenge O, Fayol A, Jannot AS, Hulot JS. Epidemiology of heart failure in young adults in France. Eur Heart J 2023; 44:383-392

Seguret M, Davidson P, Robben S, Jouve C, Pereira C, Cerveau C, Le Berre M, Rodrigues Ribeiro R, Hulot JS. A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell derived cardiomyocytes. Elife. 2024 Apr 5;12:RP87739. doi: 10.7554/eLife.87739

Pezzana C, Cras A, Simelière F, Guesdon R, Desgres M, Correa BL, Peuffier A, Bellamy V, Gouarderes S, Alberdi A, Perier MC, Pidial L, Agnely F, Bochot A, Hagège A, Silvestre JS, Menasché P. Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium. Biomaterials. 2022 Dec;291:121877.

Sun Y, Pinto C, Camus S, Duval V, Alayrac P, Zlatanova I, Loyer X, Vilar J, Lemitre M, Levoye A, Nus M, Ait-Oufella H, Mallat Z, Silvestre JS. Splenic Marginal Zone B Lymphocytes Regulate Cardiac Remodeling After Acute Myocardial Infarction in Mice.J Am Coll Cardiol. 2022 Feb 22;79(7):632-647.

Lima Correa B, El Harane N, Desgres M, Perotto M, Alayrac P, Guillas C, Pidial L, Bellamy V, Baron E, Autret G, Kamaleswaran K, Pezzana C, Perier MC, Vilar J, Alberdi A, Brisson A, Renault N, Gnecchi M, Silvestre JS, Menasché P. Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts. Theranostics. 2021 Nov 2;11(20):10114-10124.

Fayol A, Wack M, Livrozet M, Carves JB, Domengé O, Vermersch E, Mirabel M, Karras A, Le Guen J, Blanchard A, Azizi M, Amar L, Bories MC, Mousseaux E, Carette C, Puymirat E, Hagège A, Jannot AS, Hulot JS. Aetiological classification and prognosis in patients with heart failure with preserved ejection fraction. ESC Heart Fail. 2021 Nov 29. doi: 10.1002/ehf2.13717.

Lima Correa B, El Harane N, Gomez I, Rachid Hocine H, Vilar J, Desgres M, Bellamy V, Keirththana K, Guillas C, Perotto M, Pidial L, Alayrac P, Tran T, Tan S, Hamada T, Charron D, Brisson A, Renault NK, Al-Daccak R, Menasché P, Silvestre JS. Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts. Cardiovasc Res. 2021 Jan 1;117(1):292-307.

Zlatanova I, Pinto C, Bonnin P, Mathieu JRR, Bakker W, Vilar J, Lemitre M, Voehringer D, Vaulont S, Peyssonnaux C, Silvestre JS. Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury. Circulation. 2019 Mar 19;139(12):1530-1547.

El Harane N, Kervadec A, Bellamy V, Pidial L, Neametalla HJ, Perier MC, Lima Correa B, Thiébault L, Cagnard N, Duché A, Brunaud C, Lemitre M, Gauthier J, Bourdillon AT, Renault MP, Hovhannisyan Y, Paiva S, Colas AR, Agbulut O, Hagège A, Silvestre JS, Menasché P, Renault NKE. Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors. Eur Heart J. 2018 May 21;39(20):1835-1847.

Menasché P, Vanneaux V, Hagège A, Bel A, Cholley B, Parouchev A, Cacciapuoti I, Al-Daccak R, Benhamouda N, Blons H, Agbulut O, Tosca L, Trouvin JH, Fabreguettes JR, Bellamy V, Charron D, Tartour E, Tachdjian G, Desnos M, Larghero J. Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction. J Am Coll Cardiol. 2018 Jan 30;71(4):429-438.

Yaniz-Galende E, Roux M, Nadaud S, Mougenot N, Bouvet M, Claude O, Lebreton G, Blanc C, Pinet F, Atassi F, Perret C, Dierick F, Dussaud S, Leprince P, Tregouet DA, Marazzi G, Sasoon D, Hulot JS. Fibrogenic potential of PW1/Peg3 expressing cardiac stem cells. J Am Coll Cardiol 2017;70:728-741

Hulot JS, Salem JE, Redheuil A, Collet JP, Varnous S, Jourdain P, Logeart D, Gandjbakhch E, Bernard C, Hatem SN, Isnard R, Cluzel P, Le Feuvre C, Leprince P, Hammoudi N, Lemoine F, Klatzman D, Vicaut E, Komajda M, Montalescot G, Lompre AM, Hajjar RJ on behalf of the AGENT-HF investigators. Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodeling in patients with advanced systolic heart failure : Results from the AGENT-HF randomized phase 2 trial. European Journal of Heart Failure 2017 Nov;19(11):1534-1541

Ngkelo A, Richart A, Kirk JA, Bonnin P, Vilar J, Lemitre M, Marck P, Branchereau M, Le Gall S, Renault N, Guerin C, Ranek MJ, Kervadec A, Danelli L, Gautier G, Blank U, Launay P, Camerer E, Bruneval P, Menasche P, Heymes C, Luche E, Casteilla L, Cousin B, Rodewald HR, Kass DA, Silvestre JS. Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction. J Exp Med. 2016. Jun 27;213(7):1353-74.

Howangyin KY, Zlatanova I, Pinto C, Ngkelo A, Cochain C, Rouanet M, Vilar J, Lemitre M, Stockmann C, Fleischmann BK, Mallat Z, Silvestre JS. Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Co-Ordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor. Circulation. 2016 Mar 1;133(9):826-39.

Kervadec A, Bellamy V, El Harane N, Arakélian L, Vanneaux V, Cacciapuoti I, Nemetalla H, Périer MC, Toeg HD, Richart A, Lemitre M, Yin M, Loyer X, Larghero J, Hagège A, Ruel M, Boulanger CM, Silvestre JS, Menasché P, Renault NK. Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure. J Heart Lung Transplant. 2016 Jun;35(6):795-807.

Bernard L, Oh JG, Cacheux M, Lee A, Nonnenmacher M, Matasic D, Kohlbrenner E, Kho CW, Pavoine C, Hajjar RJ, Hulot JS. Cardiac Stim1 silencing impairs adaptive hypertrophy and promotes heart failure through inactivation of mTORC2/Akt signaling. Circulation, 2016, 133:1458-71