Team Leaders : Hafid Ait-Oufella and Ziad Mallat
Mail : hafid.aitoufella@inserm.fr
Phone :+33 1 53 98 80 06
Localisation : 2nd floor
Doctoral School : Ecole Doctorale Bio-Sorbonne Paris Cité
Major recent publications :
– Laurans L, Mouttoulingam N, Chajadine M, Lavelle A, Diedisheim M, Bacquer E, Creusot L, Suffee N, Esposito B, Melhem NJ, Le Goff W, Haddad Y, Paul JL, Rainteau D, Tedgui A, Ait-Oufella H, Zitvogel L, Sokol H, and Taleb S. An obesogenic diet increases atherosclerosis through promoting microbiota dysbiosis-induced gut lymphocyte trafficking into the periphery. Cell Rep. 2023 October 31, Volume 42, Issue 11
– Zhang Y, Vandestienne M, Lavillegrand JR, Joffre J, Santos-Zas I…. Silvestre JS, Tedgui A, Mallat Z, Taleb S, Lenoir O, Vindis C, Camus SM, Sokol H, Ait-Oufella H. Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy. Nat Commun. 2023 Aug 1;14(1):4622.
– Al-Rifai R, Vandestienne M, Lavillegrand JR, … Tedgui A, Lacroix M, Arrive L, Mallat Z, Taleb S, Diedisheim M, Cochain C, Rautou PE, Ait-Oufella H. JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm. Nat Commun. 2022 Nov 3;13(1):6592.
– I Santos-Zas, J Lemarié, I Zlatanova, M …. A Tedgui, Z Mallat, T Simon, B Ghaleh, JS Silvestre & H Ait-Oufella. Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling. Nat Commun. 2021 Mar 5;12(1):1483.
– Melhem NJ, ..Mallat Z, Tedgui A, Ait-Oufella H, Hulot JS, .., Silvestre JS, Taleb S. Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine. Circulation. 2021 Feb 9;143(6):566-580.
– M Vandestienne, Y Zhang, I Santos-Zas, R Al-Rifai, J Joffre, ….Guerin, E Clauser, JS Silvestre, S Lang, L Soulat-Dufour, A Tedgui, Z Mallat, S Taleb, A Boissonnas, M Derive, G Chinetti & Ait-Oufella H. TREM-1 orchestrates
Angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm. J Clin Invest. 2021 Jan 19;131(2)
– Laurans L, … Tavitian B, … Tedgui A, Mallat Z, … Taleb S. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat Med. 2018 Aug;24(8):1113-1120.
– Zeboudj L, Maître M, Guyonnet L, ….Tedgui A, Mallat Z, Tharaux PL, Ait-Oufella H. Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis. J Am Coll Cardiol. 2018 Jan 16;71(2):160-172.
