Team Leaders : Hafid Ait-Oufella and Ziad Mallat
Mail : hafid.aitoufella@inserm.fr
Phone :+33 1 53 98 80 06
Localisation : 2nd floor
Doctoral School : Ecole Doctorale Bio-Sorbonne Paris Cité
Cardiovascular diseases will remain the main cause of death within the next fifteen years forcing us to revisit their basic mechanisms and consider new therapeutic strategies.
Our group is interested in the study and modulation of innate and adaptive immune responses during atherosclerosis development, post-ischemic cardiac remodeling and aortic aneurysm formation. Furthermore, we are interested in the interplay between cardiovascular diseases and their associated co-morbidities, and more particularly, the mechanisms involved in the development of obesity and metabolic syndrome in the context of high fat diet.
Trained immunity in cardiometabolic diseases
Hafid Ait-Oufella, Ziad Mallat & Soraya Taleb
Immune cells can retain the memory of an encounter with bacteria or oxidized lipids and this memory called “trained immunity” has a lasting effect on their functions. The objective of this new project is to better understand the phenomenon of trained immunity applied to experimental cardiometabolic diseases and to dissect its cellular and molecular mechanisms.
Targeting cytotoxic immune cells in post-ischemic cardiac remodeling
Hafid Ait-Oufella
We aim to investigate with unique genetically-modified mouse models the role of NK cells, which infiltrate the heart in the context of myocardial infarction and release large amounts of cytotoxic Perforin/Granzyme B.
Intestinal cell metabolism and the control of cardiovascular diseases
Soraya Taleb
The gut microbiota may modulate cardiometabolic diseases but the mechanisms that link both gut and vascular compartments remains poorly understood. We aim to study the role of indoleamine 2, 3-dioxygenase 1 activity as well as derived metabolites in intestinal cell metabolism, gut microbiota, and cardiovascular diseases.
