1. Provost J, Garofalakis A, Sourdon J, Bouda D, Berthon B, Viel T, Perez-Liva M, Lussey-Lepoutre C, Favier J, Correia M, Pernot M, Chiche J, Pouysségur J, Tanter M, Tavitian B. Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging. Nat Biomed Eng. 2018 Feb;2(2):85-94. doi: 10.1038/s41551-018-0188-z. 

 First in vivo imaging instrument for simultaneously metabolic, vascular and anatomical imaging in rodents. Patent WO 2017/055435. Cover and comment in the Journal issue.

2. Villemain O, Correia M, Mousseaux E, Baranger J, Zarka S, Podetti I, Soulat G, Damy T, Hagège A, Tanter M, Pernot M, Messas E. Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1135-1145. doi: 10.1016/j.jcmg.2018.02.002. 

 Assessment of myocardial stiffness by shear wave elastography: development from specific acquisitions and demonstration of interest with increased stiffness in hypertrophic heart disease. e-Myosound, a start-up created from this work, develops a non-invasive sensor for measuring myocardial stiffness.

3. Hyafil F, et al. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer ⁶⁸Ga-Pentixafor for PET. J Nucl Med. 2017 Mar;58(3):499-506. 

This research work demonstrated the potential of a CXCR4-targeting probe for the detection of macrophages in atherosclerotic plaques as an alternate to FDG. In addition to the binding of the radiotracer in plaques, a specific uptake of ⁶⁸Ga-Pentixafor was detected in adrenal glands of rabbits. Following this finding, the clinical study PENTALON (Funding APHP / PentixaPharm) will start in 2024 and evaluate the diagnostic performance of ⁶⁸Ga-Pentixafor for the detection of unilateral primary hyperaldosteronism in association with Prof. L. Amar, member of Team 13. 

4. Abdel Wahab C, Jannot AS, Bonaffini PA, Bourillon C, Cornou C, Lefrère-Belda MA, Bats AS, Thomassin-Naggara I, Bellucci A, Reinhold C, Fournier LS. Diagnostic Algorithm to Differentiate Benign Atypical Leiomyomas from Malignant Uterine Sarcomas with Diffusion-weighted MRI. Radiology. 2020 Nov;297(2):361-371. doi: 10.1148/radiol.2020191658. 

New diagnostic algorithm allowing differentiating benign from malignant uterine myometrial tumours. Editorial in the journal issue and incorporation of the algorithm in international recommendations (doi: 10.1148/radiol.211658).

5. Messas E, Ijsselmuiden A, Goudot G, Vlieger S, Zarka S, Puymirat E, Cholley B, Spaulding C, Hagège AA, Mari jon E, Tanter M, Bertrand B, Rémond MC, Penot R, Ren B, den Heijer P, Pernot M, Spaargaren R. Feasibility and Performance of Noninvasive Ultrasound Therapy in Patients with Severe Symptomatic Aortic Valve Stenosis: A First-in-Human Study. Circulation. 2021 Mar 2;143(9):968-970. doi: 10.1161/CIRCULATIONAHA.120.050672. 

First-in-human evaluation of pulsed cavitational ultrasound therapy on the calcified aortic valve to reduce valve stiffness and decrease the transvalvular pressure gradient. Study carried out with the Cardiawave start-up developing the therapy device.

6. Yoganathan T, et al. . Acute stress induces long-term metabolic, functional, and structural remodeling of the heart. Nat Commun. 2023 Jun 28;14(1):3835. doi: 10.1038/s41467-023-39590-3. Erratum in: Nat Commun. 2023 Jul 12;14(1):4143. PMID: 37380648; PMCID: PMC10307856.

This multimodal study shows that acute stress induces a switch in cardiac glucose metabolism to alternative pathways that lead to long term functional changes.