About us
About PARCC
One continuum: heart · vessels · kidney
The Paris Cardiovascular Research Center (PARCC, UMR-S 970) is a Université Paris Cité and Inserm research center located at the Hôpital Européen Georges Pompidou. Our mission: understand and treat cardiovascular and renal diseases by linking their genetic and cellular mechanisms, the dialogue between organs, and observations from populations and patients.
Who we are
PARCC is an interdisciplinary research center that brings together basic scientists and clinician scientists sharing a common vision. On a single site, our teams combine molecular and cellular biology, integrative physiology, imaging, immunology, genetics and epidemiology to understand disease processes and develop new diagnostic and therapeutic strategies for vascular and cardiac diseases, hypertension, kidney diseases and transplantation.
Translational research is at the heart of our mission. Most of our senior members are hospital-university or hospital clinicians, and we work hand in hand with the clinical departments of the Hôpital Européen Georges Pompidou (cardiology, hypertension, nephrology, genetics, cardiac and vascular surgery, immunology, imaging…) to bring laboratory findings to patients.
Our history
Creation of PARCC
Inserm and Université Paris Descartes create the Paris Cardiovascular Research Center at the Hôpital Européen Georges Pompidou, with six teams and one Avenir team on a single 4,200 m² site.
A growing center
Four new teams join PARCC, broadening its expertise in vascular biology, immunology and cardiology.
13 research teams
The center is organised into 13 teams. New groups are created or join us, including Anne Eichmann’s team from the Collège de France, an Avenir team in organ transplantation (Alexandre Loupy) and Jean-Sébastien Hulot’s team.
Early career researchers
PARCC supports the creation of its early career researchers association, today known as the PARCCERs.
Structuring the Paris cardiovascular community
PARCC is a driving force in the creation of the Institute of Cardiovascular Sciences and the Graduate School Cardiovascular Sciences of Université Paris Cité.
Transplantation, innovation and a new director
Launch of the Paris Institute for Transplantation & Organ Regeneration (PITOR), and arrival on site of Polygon Therapeutics, a start-up born from PARCC research. In October 2023, Jean-Sébastien Silvestre becomes director of PARCC, succeeding Chantal Boulanger.
A new team in multi-organ dysfunction
Clément Cochain joins PARCC with an Inserm Junior Professor Chair (CPJ) and creates the team “Multi-organ dysfunction and cardiovascular pathology in metabolic diseases”.
13 research teams for a new term
For the 2025–2030 term, PARCC is organised into 13 research teams, with the creation of Ivana Zlatanova’s ATIP-Avenir team on heart regeneration and David Smadja’s team on endotheliopathy and hemostasis.
Paris Institute for Global Health
Creation of the Paris Institute for Global Health of Université Paris Cité, in which PARCC teams are closely involved.
Vision 2030 and new partnerships
PARCC defines a shared scientific identity around one continuum, heart · vessels · kidney, and three research axes, and signs a collaboration agreement with the OrganX Foundation.
Vision 2030: three research axes
Our research axes define a common scientific identity and guide our collaborations, investments and recruitments. Teams contribute to several axes, and joint programmes are co-led by at least two teams.
Genetic and molecular mechanisms
Which genetic determinants and cellular mechanisms produce disease, and where can we intervene?
From gene and cell to phenotype and intervention.
Immunometabolism and inter-organ dialogue
How do immune and metabolic interactions link organ damage and organ protection?
Immunometabolic circuits between organs.
From human cohorts to mechanisms and precision medicine
What do disease trajectories, risk and response to treatment reveal, and how can we explain them and intervene better?
From human signal to knowledge and decision.
Shared capabilities
Imaging, spatial and omics technologies, human and experimental models, biobanks and data science, supported by our technology platforms.
Directors of PARCC
Alain Tedgui
Founding director
Chantal Boulanger
Director
Jean-Sébastien Silvestre
Director
Our environment
Inserm & Université Paris Cité
PARCC is a joint research unit (UMR-S 970) of Inserm and Université Paris Cité, within its Faculty of Health.
Hôpital Européen Georges Pompidou
Located within the hospital (AP-HP), in close connection with its clinical departments and Clinical Investigation Center.
Institutes & Graduate School
PARCC teams are deeply involved in the Institute of Cardiovascular Sciences, PITOR, the Paris Institute for Global Health and the Graduate School Cardiovascular Sciences.
