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Elementor #7238

Alexandre Loupy

Multidimensional approaches to organ transplantation Paris Cardiovascular Research Center INSERM U970, Paris Institute for Transplantation and Organ Regeneration Université Paris Cité

Mail : alexandre.loupy@inserm.fr

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SCIENTIFIC TOPICS

  • Kidney, Heart, Lungs and Liver
  • Genetics, Biomarkers, Artificial Intelligence

Biosketch

Alexandre Loupy, MD PhD, is the team leader of an epidemiology research team at the National Institute of Health and Medical Research (Inserm) U970. He is also a professor of Nephrology working in the kidney transplant department of Necker Hospital. He funded the Paris Transplant Group in 2008.
 
His research focuses on artificial intelligence and multi-organ transplantation analytics. It covers allograft transplantation, rejection, antibodies and populational sciences. Pr. Loupy defended two PhDs, one in cell biology (2011) and the other in biostatistics (2014).

 

Since 2015, Pr. Loupy is the head of the Paris Expertise Centre for Organ Transplantation in PARCC U970. The Paris Transplant Group is recognised in the transplant research field for high impact factor quality epidemiologic research and has changed clinical practice with wide implementation of discoveries into clinical practice. Pr. Loupy has also been appointed Professor of Nephrology and Epidemiology Kidney Transplant department at the Necker Hospital in Paris, France in 2017 and adjunct Professor at Cedars Sinaï, UCLA, California, USA, in 2020.

 

Pr. Loupy has been appointed as Director of the Banff Scientific Committee for allograft classification in 2014 and contributes to the working groups (22 transplant centres represented worldwide), and Banff recommendations delivered to the international transplant community.

 

Pr. Loupy is also an expert for the FDA and a member of the American Society of Transplantation. He got the Clinical science investigator award from the AST in 2017 and was awarded the National Academy of Medicine Award for his work on « Renal transplantation, anti-HLA graft rejection, and biomarker identification ». Dr Loupy is also involved in the French Society of Transplantation and in the European Society of Transplantation.

 

Pr. Loupy was Associate Editor for the Transplantation Journal from 2014 to 2018, and still is at the American Journal of Transplantation. He is also referee for  the New England Journal of Medicine, Nature Medicine, The Lancet, JAMA, the American Journal of Transplantation, Kidney International, Plos Medicine and the Journal of the American Society of Nephrology.
In the past years, Pr. Loupy has obtained several grants to implement cutting edge diagnostic tests at large scale. Pr Loupy is principal investigator and coordinator of international H2020 (EU-TRAIN) and national RHU (KTD-innov, iTRANSPLANT) projects. He is also PI or co-PI of several on-going clinical trials since 2018.

Academic position

INSTITUTION

DEGREE

YEAR

FIELD

Descartes University, Paris, France

HDR*

2015

Epidemiology and Biostatistics

Descartes University, Paris, France

PhD#2

2014

Epidemiology and Biostatistics

Genetic Center University of Alberta, Canada

Post doc

2012

Genetics

Pierre et Marie Curie University, Paris, France

PhD#1

2011

Cell biology

Descartes University, Paris, France

M.D

2008

Nephrology

Responsabilities and activities

  • 2023: Director of the Paris Institute for Organ Transplantation and Regeneration (PITOR)
  • 2020: Appointed Adjunct Professor at Cedars Sinai, UCLA, Los Angeles, California USA
  • 2017: Appointed Professor of Nephrology and Epidemiology, Necker Hospital, Paris, France
  • 2015: Director of the Paris Expertise Center for Organ Transplantation (website), French National Medical Research Agency INSERM U970 Team 11 ATIP AVENIR. Paris, France
  • 2013: Associate Professor in Nephrology: Kidney Transplant department, Necker Hospital, Paris, France
  • 2011: Assistant Professor in Nephrology: Kidney Transplant department, Necker Hospital, Paris, France
  • 2010: Assistant Professor in Cardiology, Pompidou Hospital, Paris, France
  • 2002: Resident in internal Medecine, Paris Hospitals, France

Awards

  • 2023: INSERM Innovation Award
  • 2023 : Victor & Erminia Mescles Award
  • 2023: Laureate of the Senior Innovation Chair of the Institut Universitaire de France
  • Award of the ESOT European Society for Organ Transplantation (most impactful research team, 2017, 2019, 2021)
  • 2021: MIT & Stanford University: Challenges and Opportunities in Organ Allocation
  • 2021: US National Academies of Sciences –committee. (February, 5, 2021)
  • 2020: Paul I Terasaki Clinical Sciences Award
  • 2018: French National Academy of Medicine Award: prix de Académie de Médecine
  • 2017: Clinical science investigator award: American Society of Transplantation
  • 2015: French Society of Nephrology Award
  • 2009: Young Investigator Award: European Society for Organ Transplantation
  • 2008: Laureate of the gold medal of Paris Hospitals (APHP)

  • 2022 – KDIGO Expert
  • Expert for the FDA (2015, 2018, 2019)
  • 2015 – Present: Appointed Scientific Director of the International Banff Classification
 
Member of the French Society of Nephrology (SFT), the European Society for Organ Transplantation (ESOT) and the American Society of Transplantation (AST) and international society of transplantation (TTS)

Scientific summary

Our team is developing a personalized approach for transplant medicine that integrates multidimensional information derived from standard of care (clinical and biological data, histology and immunology) together with novel information coming from cutting edge technologies in immunology, molecular biology, genetics and biomarkers.