Our team consists of three groups, two in basic and one in clinical research: the Tharaux group studies the role of cell communications in pathologies that arise secondary to glomerular capillary dysfunctions or cause them. The Camerer group studies functions of G protein-coupled receptors (GPCRs) in vascular development and disease. We have a common interest in how local signalling crosstalk regulate vascular integrity and how the loss of vascular integrity exacerbates inflammatory diseases, and we both use genetic and pharmacological tools to address these questions in mouse models.

We closely work with the Department of Nephrology at the Hôpital Européen Georges-Pompidou and the Department of Internal Medicine at Hôpital Cochin, Paris, on translational and clinical aspects. Our main scientific goals are to 1. Identify mechanisms of (peri)vascular signalling in development and disease, 2. Improve our understanding of the pathogenesis of immune-mediated and metabolic vascular and glomerular diseases (primarily focal segmental glomerulosclerosis (FSGS), crescentic rapidly progressive glomerulonephritis (RPGN), diabetic retinopathy and kidney disease), 3. Identify the roles of immune cells in sickle cell vasculopathy and nephropathy.