I obtained my PhD in Cardiovascular Physiology from the University of Paris 5 in 2017. My doctoral research focused on cardiovascular pathology and the immune system, with the aim of understanding how immune cells are recruited to the ischemic heart and the critical role of macrophage signaling in this process. Notably, my work highlighted how macrophage metabolism influences heart regeneration in both neonatal and adult mice following heart injury.
Following my PhD, I joined the Cardiovascular Research Center at the University of California, San Francisco (UCSF), as a postdoctoral fellow. My research there concentrated on uncovering the genetic mechanisms underlying heart development and regenerative processes, with a particular emphasis on enhancer activity and transcription factors. This work contributed to building a comprehensive understanding of the transcriptional and epigenetic regulation of heart regeneration.
In 2025, I began my independent research career as a young investigator at the Cardiovascular Research Center (Inserm U970). I am now leading a team investigating the chromatin landscape in heart regeneration, using zebrafish and mice as model organisms. Our goal is to identify novel therapeutic strategies to combat heart failure and improve regenerative outcomes.
2011 – 2011 Bachelor student with Dr. Jacqueline London (University Paris7 Denis Diderot)
2011 – 2011 Bachelor student with Pr. Christophe Magnan (University Paris7 Denis Diderot)
2012 – 2012 Master student with Dr. Jean-Sebastien Silvestre (University Paris5 Descartes)
2013 – 2017 PhD student with Dr. Jean-Sebastien Silvestre (University Paris5 Descartes)
2015 – 2017 Consultant in heart ischemic disease at SANOFI, Paris, France
2018 – 2024 Postdoctoral Scholar with Dr. Brian Black (University of California, San Francisco)
2025 – 2030 Atip-Avenir-PARCC, Inserm U970
2025-2030 Atip-Avenir: “Decoding cell-type specific chromatin landscape to elucidate heart regeneration”
2024-2026 Lefoulon Delalande, returning grant: “Endothelial enhancers in heart regeneration”
2019-2021 American Heart Association Post-doctoral fellowship Grant: “Identification and functional characterization of endocardial enhancers”.
2016-2017 Scolarship FRM (Fondation Recherche Medical)
2013-2016 PhD fellowship, CORDDIM (Cardiovascular, Diabetes, Obesity and Kidney Society)
2018-2022 Annual Retreat Cardiovascular Research Institute (CVRI), UCSF: Best oral communication 2022, best poster presentation 2018 and 2019
2015 Best Oral Presentation at CORDDIM annual congress.
2015 Best Poster Presentation at Integrative biology in cardiovascular and metabolic diseases meeting
My work will address fundamental questions about cardiac injury-responsive enhancers in zebrafish to examine whether the development of engineered enhancers in mammals represents a novel strategy for heart regeneration. This experimental strategy, provides a unique opportunity to understand novel roles of enhancers in natural regeneration and identify innovative therapeutic modalities.
