Mission and Objectives

The PARCC is dedicated to experimental disease-oriented research and has as primary aim to catalyze and speed up the production of basic knowledge related to the understanding of the cellular and molecular basis of cardiovascular disease. Its main mission is to maintain an optimal scientific and medical environment in order to promote excellence in cardiovascular translational research.

Our overall goals for the 2014-2018 period are :

1. to pursue internationally leading laboratory-to-bedside research programs that address fundamental molecular, cellular and physiological mechanisms underlying normal and abnormal cardiovascular function and diseases ;

2. to maintain a highly collaborative, multi-disciplinary environment which catalyzes the pursuit of imaginative and innovative research programs, based on complementary expertise of the PARCC teams (cell and molecular biology, physiology/pathophysiology, pharmacology, immunology, endocrinology, genetics, epidemiology, imaging) ;

3. to link these to translational research that improves the prevention, diagnosis and treatment of human cardiovascular disease ;

4. to establish an optimal environment with cutting-edge technology ; 5. to undertake high-quality research training of non-clinical and clinical scientists.

The strategy to achieve our objectives is multifaceted, but is mainly built upon the expertise in basic and clinical translational research of the teams that started internal collaborations, as well as upon strong interactions with the clinical divisions at HEGP (cardiology, cardiovascular prevention, hypertension, medicine, genetics, cardiac and vascular surgery), as well as with the Clinical Investigation Center and the Clinical Research Unit.

Main organizational Principles

The organization of the research structure and its environ- ment crucially influence the creation of fundamental new knowledge. It is therefore of utmost importance that the PARCC recruit high quality teams involved in cardiovascular research, working in synergy with clinical laboratories and departments to bolster the translation to clinical applications. The PARCC (4,200 m2) houses 14 research groups. hospital.

Teams hosted at the PARCC have a long- Such a research structure brings together a critical standing experience of initiating and conducting clinical mass of basic and clinical scientists necessary to make studies in direct coordination with clinicians. major breakthroughs in cardiovascular biology and medicine.

Gathering cardiovascular scientists with complementary expertise (cell and molecular biology, physiology/pathophysiology, pharmacology, genetics, epidemiology) creates an environment with a degree of scientific integration that are optimal for scientific breakthroughs to occur, through intense and frequent interactions between scientists. Under these principles, the PARCC is hosting excellent research teams with a broad spectrum of expertise in cardiovascular research, and implementing cutting- edge technology to facilitate basic and disease-oriented research.

The PARCC aims to play a major role in the promotion and development of cardiovascular research in the Région Ile-de-France, through links with the CORDDIM (Domaine d’Intérêt Majeur “Cardiovasculaire – Obésité – Rein – Diabète”).

The PARCC is inserted within the International and European space of research through links of its research teams with EU funded European Networks and Transatlantic Leducq Foundation Networks. In addition, it acts to develop formal links with international academic institutions.
Clinical research is conducted in coordination with the Clinical Investigation Center (CIC) at HEGP (director : Pr. Michel Azizi). Basic and clinician researchers of the PARCC are encouraged to initiate clinical trials in coordination with and with the help of the clinical research laboratories and the clinical care departments of the

Governance And Management

Governing Rules

Scientific creativity is an individual act meant to provide the simplest, adequate explanation of the facts. “Science and art are interpretative activities—they are both about meaning and they both use models and metaphors to make the invisible visible, to provide some sort of explanation1”.
However, the individualism of the artist is opposed to the self-effacing collectivism of the scientists, and to implement a research project aimed at confirming or infirming a hypothesis, scientists definitely need collaborations. Success in a research center environment requires new patterns of interaction among biomedical scientists, and depends on the combination of the skills and talents of many investigators applied to the solution of a common problem.

With that in mind, a research structure and its governance must be fully dedicated to improving, facilitating and fostering the implementation of collaborations to the benefits of individual creativity and brightness.
The structure of the PARCC is stringently modeled to be able :
1. to orchestrate a diverse group of scientists in the present and at the same time to orient a scientific staff toward future directions, and
2. to respond quickly to exciting new research opportunities, by providing financial and administrative assistance. 1 frazzetto g. different and yet alike. eMbo reports, 2004, 5: 233-235.

Governing Structure

All decisions concerning budget, investments, and the development of the Center have to be approved by the Assembly of the team leaders. To coordinate the activities and administration of the PARCC a Managing Director is employed.

In order to operate and coordinate the activities of the PARCC, the Director and the Assembly of the team leaders are supported by a Scientific Advisory Board and an Operational Management Group (OMG). The Scientific Advisory Board provides advice and monitoring. The Operational Management Group is responsible for the implementation of Board decisions and the day-to-day management of the Center.