Pathophysiology of the Renal Circulation
Team Leader : Pierre-Louis Tharaux
1- Mechanisms that govern the fate of podocytes and parietal epithelial cells in immune-mediated, hypertensive and diabetic glomerulopathies.
2- The role of interstitial pericytes in fibrotic kidney remodelling.
3- Leukocyte-endothelial interactions in experimental sickle cell disease leading to vaso-occlusive events and chronic kidney damage (FSGS).
Research in this laboratory is centered on the genetic analysis of mouse vascular and renal pathophysiology, with a particular emphasis on genes implicated in signaling pathways. Our work covers three areas :
GPCRs and RTK signalling in podocytes in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)
Signalling in podocytes and endothelial cells in Sickle Cell Nephropathy and Vasculopathy and in Diabetic Nephropathy.
Mechanisms of interstital fibrosis and fibrillar collagen assembly in hypertension and immune kidney injury.More
Flamant M, Bollée G, Hénique C, Tharaux PL Epidermal growth factor: a new therapeutic target in glomerular disease. Nephrol Dial Transplant. 2012; 27: 1297–1304
Hénique C, Tharaux PL Targeting signaling pathways in glomerular diseases. Current Op Nephrol Hypertens 2012; in press
Tharaux PL, Barton M Endothelin and the podocyte. Clin Kidney J . 2012; 5(1): 17-27; in pressAll the publications