Pathophysiology of the Renal Circulation
Team Leader : Pierre-Louis Tharaux
1- The role of GPCRs and RTK signalling in podocytes, parietal epithelial cells and endothelial cells in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)
2- Podocyte-endothelial cross talk in the progression of Diabetic Nephropathy and Vasculopathy and in Sickle Cell Nephropathy and Vasculopathy.
3- Leukocyte-endothelial interactions in experimental sickle cell disease leading to vaso-occlusive events and chronic kidney damage (FSGS).
Research in this laboratory is centered on the genetic analysis of mouse vascular and renal pathophysiology, with a particular emphasis on genes implicated in signaling pathways. Our work covers three areas :
GPCRs and RTK signalling in podocytes and endothelial cells in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)
Signalling in podocytes and endothelial cells in Sickle Cell Nephropathy and Vasculopathy
Podocyte-endothelial cell cross-talk in the progression of Diabetic Nephropathy and Vasculopathy.More
Pierre-Louis THARAUX, MD, PhD, DR Inserm
Magali JASIEK, MD
Bollée G*, Flamant M*, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E,
Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL.
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.
Nat Med. 2011 . Sep 25;17(10):1242-50. doi: 10.1038/nm.2491. *: equal contribution
Casanova D, Bouzigues C, Nguyên TL, Ramodiharilafy RO, Bouzhir-Sima L, Gacoin T, Boilot JP, Tharaux PL, Alexandrou A.
Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells.
Nat Nanotechnol. 2009;4(9):581-5. PMID: 19734931
Sabaa N, de Franceschi L, Bonnin P, Castier Y, Malpeli G, Debbabi H, Galaup A, Maier-Redelsperger M, Vandermeersch S, Scarpa A, Janin A, Levy B, Girot R, Beuzard Y, Leboeuf C, Henri A, Germain S, Dussaule J-C, Tharaux P-L.
Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle cell disease.
J. Clin. Invest. 2008 ; 118(5):1924-33. PMID: 18382768