Pathophysiology of the Renal Circulation

Team Leader : Pierre-Louis Tharaux

Main topics:
1- The role of GPCRs and RTK signalling in podocytes, parietal epithelial cells and endothelial cells in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)

2- Podocyte-endothelial cross talk in the progression of Diabetic Nephropathy and Vasculopathy and in Sickle Cell Nephropathy and Vasculopathy.

3- Leukocyte-endothelial interactions in experimental sickle cell disease leading to vaso-occlusive events and chronic kidney damage (FSGS).

Objective

Research in this laboratory is centered on the genetic analysis of mouse vascular and renal pathophysiology, with a particular emphasis on genes implicated in signaling pathways. Our work covers three areas :

GPCRs and RTK signalling in podocytes and endothelial cells in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)

Signalling in podocytes and endothelial cells in Sickle Cell Nephropathy and Vasculopathy

- Podocyte-endothelial cell cross-talk in the progression of Diabetic Nephropathy and Vasculopathy.

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The Team

Scientist :
Pierre-Louis THARAUX, MD, PhD, DR Inserm

Post-doctoral Fellows :
Carole HENIQUE-GRECIET, PhD
Olivia LENOIR, PhD
Christina PAPISTA, PhD
Jin HUANG, PhD
Giulia GHINATTI, PhD

PhD students :
Mikael MAITRE, MSc
Imane BENSAADA, MSc
Léa GUYONNET, MSc

Engineer and lab managers :
Kathleen FLOSSEAU, BS
Pierre NIVOIT, PhD
Anna CHIPONT

Master students:
Magali JASIEK, MD

Publications

Bollée G*, Flamant M*, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL.
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.
Nat Med. 2011 . Sep 25;17(10):1242-50. doi: 10.1038/nm.2491. *: equal contribution

Casanova D, Bouzigues C, Nguyên TL, Ramodiharilafy RO, Bouzhir-Sima L, Gacoin T, Boilot JP, Tharaux PL, Alexandrou A.
Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells.
Nat Nanotechnol. 2009;4(9):581-5. PMID: 19734931

Sabaa N, de Franceschi L, Bonnin P, Castier Y, Malpeli G, Debbabi H, Galaup A, Maier-Redelsperger M, Vandermeersch S, Scarpa A, Janin A, Levy B, Girot R, Beuzard Y, Leboeuf C, Henri A, Germain S, Dussaule J-C, Tharaux P-L.
Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle cell disease.
J. Clin. Invest. 2008 ; 118(5):1924-33. PMID: 18382768

All the publications