Pathophysiology of the Renal Circulation

Team Leader : Pierre-Louis Tharaux

Main topics:
1- Mechanisms that govern the fate of podocytes and parietal epithelial cells in immune-mediated, hypertensive and diabetic glomerulopathies.

2- The role of interstitial pericytes in fibrotic kidney remodelling.

3- Leukocyte-endothelial interactions in experimental sickle cell disease leading to vaso-occlusive events and chronic kidney damage (FSGS).

Research in this laboratory is centered on the genetic analysis of mouse vascular and renal pathophysiology, with a particular emphasis on genes implicated in signaling pathways. Our work covers three areas :

GPCRs and RTK signalling in podocytes in response to immune injury (RPGN), hypertension, and in focal segmental glomerulosclerosis (FSGS)

Signalling in podocytes and endothelial cells in Sickle Cell Nephropathy and Vasculopathy and in Diabetic Nephropathy.

Mechanisms of interstital fibrosis and fibrillar collagen assembly in hypertension and immune kidney injury.

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Scientist :
Pierre-Louis THARAUX, MD, PhD, DR Inserm

Post-doctoral Fellows :
Carole HENIQUE-GRECIET, PhD
Olivia LENOIR, PhD

PhD students :
Jin HUANG, MSc
Mikael MAITRE, MSc
Imane BENSAADA, MSc

Engineer and lab managers :
Léa GUYONNET, MSc
Anna CHIPONT

Master students:
Benoît CLEMENT
Magali JASIEK