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Objective

 

NEWS ! The team is recruiting a post-doctoral fellow to work on cell metabolism in kidney inflammation. Post-doc in team 8

Our team consists of three groups, two in basic and one in clinical research : the Camerer group studies functions of G protein- coupled receptors (GPCRs) in vascular development and disease, and the Tharaux group studies the role of GPCRs and receptor tyrosine kinases (RTKs) in pathologies that arise secondary to glomerular capillary dysfunctions or cause them. We have a common interest in how these receptor families regulate vascular integrity and how loss of vascular integrity exacerbates inflammatory disease, and we both use genetic and pharmacological tools to address these questions in mouse models. We closely work with the Department of Nephrology directed by Eric Thervet at the Hôpital Européen Georges-Pompidou on translational aspects. Our main scientific goals are to : 1. Identify roles for and mechanisms of GPCR signaling in development and disease, 2. Improve our understanding of the pathogenesis of vascular and glomerular diseases (primarily focal segmental glomerulosclerosis (FSGS), Sickle cell nephropathy, crescentic rapidly progressive glomerulonephritis (RPGN), diabetic nephropathy) with endothelial and podocyte damage, with emphasis on pathological crosstalk between GPCRs and RTKs, 3. Identify critical switches in the pathogenesis of glomerular diseases with focus on GPCRs and RTKs.

 

Micro-poétique -©Iglika Christova 2018

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