Anne Eichmann – Team Leader

anne eichmannAnne Eichmann – Team Leader

Team 9: Vascular development and disease

 

The scientific interests of the group relate to the cellular and molecular mechanisms that direct formation of a branched vascular network. Blood vessels networks are of considerable size – about 60.000 miles of vessels in every human being. Despite their size and complexity, vessel networks develop in a highly stereotyped fashion, with major vessels in different organs and the limbs all forming at designated sites. Blood vessel networks ramify together with nerves of the peripheral nervous system throughout the body. Our work reveals cellular and molecular principles used by vessels and nerves to orchestrate the formation of their branched networks. We are investigating how alterations of these basic principles participate in cardiovascular disease.

 

CURRENT POSITIONS———————————————————————————————————————————————————–

2015 –       DR1 Inserm, Inserm U970, Paris Cardiovascular Research Center, France

2012 –       Professor of Cellular and Molecular Physiology, Yale University School of Medicine,

.                .New Haven, CT, USA USA

2012-         Ensign Professor of Medicine, Cardiology Department, Yale University

2010 –       Professor of Medicine, Cardiology Department, Yale University

 

PREVIOUS POSITIONS———————————————————————————————————————————————————–

2007 – 15   Research Director 1st class (DR1), Inserm U833, Collège de France, France

2007 – 11   Director, Inserm U833 ‘developmental and pathological angiogenesis’, Collège de France

2009 – 11   Director, Federative Research Institute (IFR52), Collège de France, Paris

2001 – 06   Inserm Avenir Young Investigator, Inserm U36, Collège de France, Paris

2005 – 07   DR2 INSERM, Inserm U36, Collège de France

2002 – 05   Research Director 2nd class (DR2) CNRS, Inserm U36, Collège de France, Paris

2000          Harvard Medical School, Boston, USA (Prof. Andrew Lassar)

1997 – 02   Research fellow 1st class (CR1), Centre National de la Recherche Scientifique CNRS,

.                .Institut d’Embryologie, Nogent-sur-Marne, France

1996          EMBO fellow, Haartman Cancer Research Institute, Helsinki University, Finland (Prof. Kari .                .Alitalo)

1994-96     Postdoctoral fellow, Institut d’Embryologie, Nogent-sur-Marne, France (Prof. Nicole

.                .Le Douarin)

1994          Kyoto University, Japan (Prof. Shin-Ichi Nishikawa)

 

ORGANISATION OF SCIENTIFIC MEETINGS ————————————————————————————————————————————————

2018          Keystone Angiogenesis meeting, co-organizer

2015          Chair, Gordon conference vascular cell biology, Ventura, CA, USA

2015          Symposium Organizer and Chair, AAA at EB, Boston MA

2014          Chair, Kloster Seeon Angiogenesis meeting, Germany

2012          Keystone Angiogenesis meeting, co-organizer

 

INSTITUTIONAL RESPONSIBILITIES———————————————————————————————————————————————————–

2015-              Yale Scholar awards committee member

2008 – 12        Member, Inserm Scientific Research Council

2007 – 12        Member, Inserm Avenir young investigator selection committee

 

REVIEWING ACTIVITIES ———————————————————————————————————————————————————–

2013 – 19        NIH Cardiovascular Development and Differentiation study section member

2013 – 18        French National Cancer Institute (INCA) Scientific Advisory Board

2011 – 12        European research council remote grant reviewer

2010               European Research Council starting grant LS4 panel member

2009 –             Member, Fondation Lefoulon Delalande fellowship board

2009 – 11        Editorial board member, Physiology reviews

2008               Ad Hoc Member, French National Cancer Institute INCA

2008               Member, CRUK London Research Institute quinquennial review

2006 – 11        Member, French Cancer Research Association (ARC) board

2006               Board member, Agence Nationale de la Recherche, ‘Programme blanc’

2006 – 14        Roche research fellowship selection board

2004 –              Reviewer for Nature, Cell, Science and associated journals, JCI, Circulation, Circ Res,

.                      .Elife, PNAS and others.

 

MEMBERSHIPS OF SCIENTIFIC SOCIETIES ———————————————————————————————————————————————————–

North American Vascular Biology organization (NAVBO)

2017-              Meritorious Awards committee member

2012-2015      Council member

 

FUNDING———————————————————————————————————————————————————–

Project Title Funding source Period Role of the PI
BreakingBarriers ERC Advanced

grant

10/1/2019-

30/9/2024

Coordinator
BrainWash ANR 10/10/17-30/09/20 Coordinator
AngioInvasion ARC 10/05/17-10/05/20 Coordinator
Live Imaging of the cerebral vasculature FRM 15/05/18-14/05/21 Partner
ClearBrain

 

FRC 10/08/17-09/08/19 Partner

 

HONORS AND AWARDS———————————————————————————————————————————————————–

2019 : Judah Folkman Award NAVBO, 2018: EMBO plenary lecture, IVBM, 2013: Elected EMBO member, 2009: Liliane Bettencourt prize for Life Sciences, 2009: Chevalier de l’ordre national du mérite, 2008: Inserm Research Award, 2006: Jean Bernard award from the Medical Research Foundation FRM, 2006: Young investigator award, Simone and Cino Del Duca Foundation, 2005: renewal of INSERM Avenir award for two years based on excellent performance, 2002: Young investigator award, Schlumberger Foundation, 2002: INSERM young investigator Avenir award, 1999: Young investigator award, Ministère de l’Education et de la Recherche (ACI), 1996: EMBO short-term fellowship award.

 

TEACHING ACTIVITIES———————————————————————————————————————————————————–

2001 – 18 2-4 courses/year for MD and PhD students, Paris University 5 and 6, Yale University (since 2012), 3-7 lectures/year at French and international Institutes, 6-7 lectures at international meetings/year, 2-3 PhD committees/year at French and international Institutes

 

10 PUBLICATIONS 2015-2019———————————————————————————————————————————————————–

Rama N, Dubrac A, Mathivet T, Ní Chárthaigh RA, Genet G, Cristofaro B, Pibouin-Fragner L, Ma L, Eichmann A*, Chédotal A*. *equal contribution. Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nature Med 2015; 21: 483-91.

Aspalter IM, Gordon E, Dubrac A, Ragab A, Narloch J, Vizán P, Geudens I, Collins RT, Franco CA, Abrahams CL, Thurston G, Fruttiger M, Rosewell I, Eichmann A*, Gerhardt H*. *equal contribution. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nature Comm 2015; 6: 7264.

Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Targeting NCK-mediated endothelial cell front-rear polarity inhibits neovascularization. Circulation 2016; 133: 409-21.

Pardanaud L, Pibouin-Fragner L, Dubrac A, Mathivet T, English I, Brunet I, Simons M, Eichmann A. Sympathetic innervation promotes arterial fate by enhancing endothelial ERK activity. Circ Res 2016; 119: 607-20.

Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, Tong R, Dubrac A, Eichmann A. The Robo4 cytoplasmic domain is dispensable for vascular barrier protection and inhibition of neovascularization. Nature Comm 2016; 7: 13517.

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh SP, Eichmann A. PI3 Kinase inhibition improves vascular malformations in mice with hereditary hemorrhagic telangiectasia type 2. Nature Comm 2016; 7: 13650.

Mathivet T, Bouleti C, Van Woensel M, Stanchi F, Verschuere T, Phng LK, Dejaegher J, Balcer M, Matsumoto K, Georgieva PB, Belmans J, Sciot R, Stockmann C, Mazzone M, De Vleeschouwer S, Gerhardt H. Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth. EMBO Mol Med. 2017; 9: 1629-1645.

Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa WC, Dubrac A, Eichmann A. SMAD4 prevents flow induced arteriovenous malformations by inhibiting Casein Kinase 2. Circulation 2018; 138: 2379-94.

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boye K, Michon P, Künzel S, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernandez-Hernando C, Shulman GI, Sessa WC, Eichmann A. Lacteal junction zippering protects against diet-induced obesity. Science 2018; 361: 599-603.

Dubrac A, Künzel SE, Künzel SH, Li J, Chandran RR, Martin K, Greif D, Adams RH, Eichmann A. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Comm 2018; 9: 3463.